Carotenoids obi
All carotenoids     All organisms     All pathways     All reactions     Feedback CarotenoidsDB: Multidrug resistance protein inhibitors
welcome
  [   About  |   Help  |   Search carotenoid entry  |   Search organism entry  |   Search similar carotenoids  |   Predict biological activities of a carotenoid  ]


   CA00435  Aurochrome
  • Moderately inhibits MDR in hMDR1-L1210, at 4 and 40 microgram/ml (Ref.493).

  •    CA00403  Luteochrome
  • Weak MDR reversal activity in mdr1-L1210 and doxorubicin-resistant MCF-7 (Ref.493).

  •    CA00441  (8'R)-Luteoxanthin
  • Reverse MDR in MCF-7 cells and potentiate epirubicin antiproliferative activity in L5178 (Ref.492).

  •    CA00442  (8'S)-Luteoxanthin
  • Reverse MDR in MCF-7 cells and potentiate epirubicin antiproliferative activity in L5178 (Ref.492).

  •    CA00976  (9Z)-Violaxanthin
  • Effective MDR modulator (Ref.493, Ref.582).

  •    CA00747  Capsochrome
  • Efficiently reverse MDR activity (Ref.493).

  • Ref.493 : Anne-Laure Gagez, Valérie Thiery, Virginie Pasquet, Jean-Paul Cadoret, and Laurent Picot, Current Bioactive Compounds 2012, 8, 000-000, "Epoxycarotenoids and Cancer. Review".
  • Ref.492 : Péter Molnár, József Deli, Toru Tanaka,Yoshiyuki Kann, Satoru Tani, Nóra Gyémánt, Joseph Molnár ,and Masami Kawase, Phytotherapy Research, Volume 24, Issue 5, pages 644–648, May 2010, “Carotenoids with anti-Helicobacter pylori activity from Golden deliciousapple”.
  • Ref.582 : Gyémánt N, Tanaka M, Molnár P, Deli J, Mándoky L, Molnár J., Anticancer Res. 2006 Jan-Feb;26(1A):367-74., PMID: 16475720, "Reversal of multidrug resistance of cancer cells in vitro: modification of drug resistance by selected carotenoids.".
  • Since June 15, 2015 by Junko Yabuzaki.