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Entry
CR00023                                                            
Classification
Name
carotenoid-15,15'-cleaving oxygenase (tetatively assigned by Carotenoids DB)
Definiton
β-Apo-8'-carotenal + O2 = Retinal + Apo-8',15'-carotenedial
Substrate
CA00825 β-Apo-8'-carotenal (8'-al, 8'-apo, beta)
Product
CA00807 Retinal (15-al, 15-apo, beta)
Comment

Structure change

Chemical Fingerprint Changes 
Chemical Fingerprint Changes 
(improved)
Chemical Fingerprint Changes 
(improved ver.2)
EC number
1.13.11.75; 1.13.11.65
Protein Name
NosACO, CarX
Organism(s) in references
Nostoc sp. PCC7120; Fusarium fujikuroi; Mycobacterium tuberculosis
Data sources/References
  • Ref.560 : Scherzinger D, Ruch S, Kloer DP, Wilde A, Al-Babili S., Biochem J. 2006 Sep 15;398(3):361-9., PMID: 16759173 PMCID: PMC1559462 DOI: 10.1042/BJ20060592, "Retinal is formed from apo-carotenoids in Nostoc sp. PCC7120: in vitro characterization of an apo-carotenoid oxygenase."
  • Ref.561 : Alfonso Prado-Cabrero, Daniel Scherzinger, Javier Avalos, and Salim Al-Babili, EUKARYOTIC CELL, Vol.6, No.4, Apr. 2007, p. 650–657, doi:10.1128/EC.00392-06, "Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX from Fusarium fujikuroi"
  • Ref.557 : Daniel Scherzinger, Erdmann Scheffer, Cornelia Bar, Hansgeorg Ernst and Salim Al-Babili, FEBS J. 2010 Nov;277(22):4662-73. doi: 10.1111/j.1742-4658.2010.07873.x. Epub 2010 Oct 4."The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids"
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