Carotenoids obi
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                            (Actinobacteria: normal inhabitant of human, same as Micrococcus lysodeikticus)
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☀ Pathway reconstructed carotenoids:       [  Search similar carotenogenesis pathway constructing organisms  ]  
  1. CA00597 (Lutein)
  2. CA00908 (Nonaflavuxanthin)
  3. CA00913 (2-(4-Hydroxy-3-methylbut-2-enyl)-7,8,7',8'-tetrahydro-epsilon,psi-carotene)
  4. CA00914 (2-(4-Hydroxy-3-methylbut-2-enyl)-beta,beta-carotene)
  5. CA00917 (Flavuxanthin)
  6. CA00940 (7,8 (or 7',8')-Dihydrosarcinaxanthin)
  7. CA00942 (Sarcinaxanthin)
  8. CA00943 (Sarcinaxanthin monoglucoside)
  9. CA00944 (Sarcinaxanthin diglucoside)
☀ Pathway unconstructed carotenoids: CA00940 (7,8 (or 7',8')-Dihydrosarcinaxanthin)
☀ Lycopene biosynthesis type: Bacterial type (Ref.690)

  ☀ CA00043 (Lycopene) biosynthesis pathway

   Path: CA00189 (Prephytoene pyrophosphate (diphosphate)) -> CA00060 (Phytoene) -> CA00058 ((all-E)-Phytofluene) -> CA00051 (ζ-Carotene) -> CA00047 (Neurosporene) -> CA00043 (Lycopene)

   See: CB000005 (Bacterial and fungal pathway: CA00189 -> CA00060 -> CA00058 -> CA00051 -> CA00047 -> CA00043)

   Necessary enzymes for those reactions in theory: CrtB(2.5.1.32), CitPsy(2.5.1.32), AtPSY(2.5.1.32) (CR00277: CA00189 -> CA00060) --> Crtlb(1.3.99.28), CrtI(1.3.99.28, 1.3.99.30, 1.3.99.31), Crtlb(1.3.99.28), PDS(1.3.99.29), Crtla(1.3.99.29) (CR00389: CA00060 -> CA00058) --> CrtI(1.3.99.28, 1.3.99.30, 1.3.99.31), Crtlb(1.3.99.28), PDS(1.3.5.5, 1.3.99.29), Crtla(1.3.99.29) (CR00115: CA00058 -> CA00051) --> PDS(1.3.5.5, 1.3.99.29), CitPDS1(1.3.5.5), BoPDS(1.3.5.5), CrtI(1.3.5.6, 1.3.99.28, 1.3.99.30, 1.3.99.31), Crtlb(1.3.99.28), CrtQa(1.3.5.6), CrtQb(1.3.5.6), ZDS(1.3.5.6) (CR00136: CA00051 -> CA00047) --> CrtI(1.3.5.6, 1.3.99.30, 1.3.99.31), CrtQa(1.3.5.6), CrtQb(1.3.5.6), ZDS(1.3.5.6), Crtlb(1.3.99.26) (CR00132: CA00047 -> CA00043)




  ☀ CA00597 (Lutein) biosynthesis pathway

   Path: CA00043 (Lycopene) -> CA00298 (δ-Carotene) -> CA00587 (α-Carotene) -> CA00592 (Zeinoxanthin) -> CA00597 (Lutein)

   See: CB000033 (Knwon path in general: CA00043 -> CA00298 -> CA00587 -> CA00592 -> CA00597)

   Necessary enzymes for those reactions in theory: CrtL-e(5.5.1.18), LCYe(5.5.1.18) (CR00377: CA00043 -> CA00298) --> LCYb, CrtL(5.5.1.19), CrtL-b(5.5.1.19), CrtL-e(5.5.1.19) (CR00367: CA00298 -> CA00587) --> LUT5/CYP97A3, CrtR-b (CR00199: CA00587 -> CA00592) --> LUT1/CYP97C1 (CR00197: CA00592 -> CA00597)




  ☀ CA00913 (2-(4-Hydroxy-3-methylbut-2-enyl)-7,8,7',8'-tetrahydro-epsilon,psi-carotene) biosynthesis pathway

   Path: CA00043 (Lycopene) -> CA00908 (Nonaflavuxanthin) -> CA00913 (2-(4-Hydroxy-3-methylbut-2-enyl)-7,8,7',8'-tetrahydro-epsilon,psi-carotene)

   See: CB000099 (Knwon path in Corynebacterium: CA00043 -> CA00908), Proposed reaction (CA00908 -> CA00913)

   Necessary enzymes for those reactions in theory: CrtE2 (CR00321: CA00043 -> CA00908) --> unknown (CA00908 -> CA00913)




  ☀ CA00914 (2-(4-Hydroxy-3-methylbut-2-enyl)-beta,beta-carotene) biosynthesis pathway

   Path: CA00043 (Lycopene) -> CA00908 (Nonaflavuxanthin) -> CA00912 (7',8',11',12'-Dehydrononaprenoxanthin) -> CA00914 (2-(4-Hydroxy-3-methylbut-2-enyl)-beta,beta-carotene)

   See: CB000099 (Knwon path in Corynebacterium: CA00043 -> CA00908), Proposed reaction (CA00908 -> CA00912), Proposed reaction (CA00912 -> CA00914)

   Necessary enzymes for those reactions in theory: CrtE2 (CR00321: CA00043 -> CA00908) --> unknown (CA00908 -> CA00912) --> unknown (CA00912 -> CA00914)




  ☀ CA00944 (Sarcinaxanthin diglucoside) biosynthesis pathway

   Path: CA00043 (Lycopene) -> CA00908 (Nonaflavuxanthin) -> CA00917 (Flavuxanthin) -> CA00942 (Sarcinaxanthin) -> CA00943 (Sarcinaxanthin monoglucoside) -> CA00944 (Sarcinaxanthin diglucoside)

   See: CB000101 (Knwon path in Micrococcus: CA00043 -> CA00908 -> CA00917 -> CA00942 -> CA00943 -> CA00944)

   Necessary enzymes for those reactions in theory: CrtE2 (CR00321: CA00043 -> CA00908) --> CrtE2 (CR00322: CA00908 -> CA00917) --> CrtYg and CrtYh (CR00378: CA00917 -> CA00942) --> CrtX (CR00302: CA00942 -> CA00943) --> CrtX (CR00303: CA00943 -> CA00944)



Ref.690 : Enfissi EM, Nogueira M, Bramley PM, Fraser PD, Plant J. 2017 Feb;89(4):774-788. doi: 10.1111/tpj.13428. Epub 2017 Feb 7., "The regulation of carotenoid formation in tomato fruit.", PMID: 27865019 DOI: 10.1111/tpj.13428
Since June 15th, 2015 by Junko Yabuzaki.