1. Oxidoreductions of C40 beta,beta carotenoid
        Cleavage and aldehyde addition
            Reaction center(s): C15 in beta,beta carotenoid

beta,beta  ->  15-al, 15-apo, beta
( Help )

beta'  ->  15-al, 15-apo

beta'  ->  15-al, 15-apo

Nostoc sp. PCC7120, Nostoc sp. strain PCC 7120; Fusarium fujikuroi, Haloarcula japonica (Ref.621), Mycobacterium tuberculosis (Ref.557)

Ref.560 : Scherzinger D, Ruch S, Kloer DP, Wilde A, Al-Babili S., Biochem J. 2006 Sep 15;398(3):361-9., PMID: 16759173 PMCID: PMC1559462 DOI: 10.1042/BJ20060592, "Retinal is formed from apo-carotenoids in Nostoc sp. PCC7120: in vitro characterization of an apo-carotenoid oxygenase."

Ref.550 : Erin K. Marasco, Kimleng Vay, and Claudia Schmidt-Dannert, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 281, NO. 42, pp. 31583–31593, October 20, 2006, "Identification of Carotenoid Cleavage Dioxygenases from Nostoc sp. PCC 7120 with Different Cleavage Activities"

Ref.561 : Alfonso Prado-Cabrero, Daniel Scherzinger, Javier Avalos, and Salim Al-Babili, EUKARYOTIC CELL, Vol.6, No.4, Apr. 2007, p. 650–657, doi:10.1128/EC.00392-06, "Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX from Fusarium fujikuroi"

Ref.621 : Ying Yang, Rie Yatsunami, Ai Ando, Nobuhiro Miyoko, Toshiaki Fukui, Shinichi Takaichi, Satoshi Nakamura, "Complete Biosynthetic Pathway of the C50 Carotenoid Bacterioruberin from Lycopene in the Extremely Halophilic Archaeon Haloarcula japonica", Journal of Bacteriology, May 2015 Volume 197 Number 9

Ref.557 : Daniel Scherzinger, Erdmann Scheffer, Cornelia Bar, Hansgeorg Ernst and Salim Al-Babili, FEBS J. 2010 Nov;277(22):4662-73. doi: 10.1111/j.1742-4658.2010.07873.x. Epub 2010 Oct 4."The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids"

KEGG ENZYME: 1.13.11.51, 1.13.11.75
BRENDA: 1.13.11.51, 1.13.11.75
IUBMB: 1.13.11.51, 1.13.11.75