Carotenoids obi
All carotenoids     All organisms     All pathways     All reactions     Feedback
Carotenoids DB          Carotenoids DB: CR00050   
  [   About  |   Help  |   Search carotenoid entry  |   Search organism entry  |   Search similar carotenoids  |   Predict biological activities of this carotenoid   ]
Entry
CR00050                                                            

Classification
Name
carotenoid-15,15'-oxygenase (tetatively assigned by Carotenoids DB)
Definiton
β-Carotene + O2 = Retinal (Not capable by Nostoc)
Substrate
CA00309 β-Carotene (beta,beta)
Product
CA00807 Retinal (15-al, 15-apo, beta)
Comment

Structure change

Chemical Fingerprint Changes 
Chemical Fingerprint Changes 
(improved)
Chemical Fingerprint Changes 
(improved ver.2)
EC number
1.13.11.51; 1.13.11.75
Protein Name
CCD, CarX, NosACO, Brp
Organism(s) in references
Nostoc sp. PCC7120, Nostoc sp. strain PCC 7120; Fusarium fujikuroi, Haloarcula japonica (Ref.621), Mycobacterium tuberculosis (Ref.557)
Data sources/References
  • Ref.560 : Scherzinger D, Ruch S, Kloer DP, Wilde A, Al-Babili S., Biochem J. 2006 Sep 15;398(3):361-9., PMID: 16759173 PMCID: PMC1559462 DOI: 10.1042/BJ20060592, "Retinal is formed from apo-carotenoids in Nostoc sp. PCC7120: in vitro characterization of an apo-carotenoid oxygenase."
  • Ref.550 : Erin K. Marasco, Kimleng Vay, and Claudia Schmidt-Dannert, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 281, NO. 42, pp. 31583–31593, October 20, 2006, "Identification of Carotenoid Cleavage Dioxygenases from Nostoc sp. PCC 7120 with Different Cleavage Activities"
  • Ref.561 : Alfonso Prado-Cabrero, Daniel Scherzinger, Javier Avalos, and Salim Al-Babili, EUKARYOTIC CELL, Vol.6, No.4, Apr. 2007, p. 650–657, doi:10.1128/EC.00392-06, "Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX from Fusarium fujikuroi"
  • Ref.621 : Ying Yang, Rie Yatsunami, Ai Ando, Nobuhiro Miyoko, Toshiaki Fukui, Shinichi Takaichi, Satoshi Nakamura, "Complete Biosynthetic Pathway of the C50 Carotenoid Bacterioruberin from Lycopene in the Extremely Halophilic Archaeon Haloarcula japonica", Journal of Bacteriology, May 2015 Volume 197 Number 9
  • Ref.557 : Daniel Scherzinger, Erdmann Scheffer, Cornelia Bar, Hansgeorg Ernst and Salim Al-Babili, FEBS J. 2010 Nov;277(22):4662-73. doi: 10.1111/j.1742-4658.2010.07873.x. Epub 2010 Oct 4."The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids"
  • Links to other DB

       Search other references with Google Scholar