 | CA00043 LycopenePrevention of lipopolysaccharide-induced Alzheimer’s disease in the preclinical studies by increasing the expression of nuclear Nrf2, HO-1, NQO-1, SOD, CAT, and GSH in Nrf2/ARE antioxidant pathway. (Ref.783)
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 | CA00309 β-CaroteneAnti-Alzheimer effects on mice related to the involvement of the Nrf2/ARE pathway. (Ref.784)
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 | CA00328 ZeaxanthinAnti-amyloid aggregation activity similar to cryptocapsin-5,6-epoxide (Half maximal inhibitory concentration = 2.29μM) (Ref.765).
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 | CA00597 LuteinAnti-apoptic agent - preventing loss of Bcl2 and Bcl-xL, preventing accumulation of Bax, preventing accumulation or release of Cytochrome C, and preventing accumulation or activation of Caspase 3 (Ref.782). Fucoxanthin potentially binds directly to amyloid-β, preventing formation of pathological amyloid-beta fibril (Ref.782).
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 | CA00737 CryptocapsinHigh bioactivity of anti-amyloid aggregation (Half maximal inhibitory concentration =1.97μM) (Ref.765).
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Ref.782 : Han-A Park et al., Molecules 2020, 25, 3453, “Anti-Apoptotic Effects of Carotenoids in Neurodegeneration”, doi:10.3390/molecules25153453.
Ref.783 : Wang, J.; Li, L.; Wang, Z.; Cui, Y.; Tan, X.; Yuan, T.; Liu, Q.; Liu, Z.; Liu, X. , J. Nutr. Biochem. 2018, 56, 16–25., “Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress.” .
Ref.784 : Hira, S.; Saleem, U.; Anwar, F.; Sohail, M.F.; Raza, Z.; Ahmad, B., Biomolecules 2019, 9, 441. “β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease. .
Ref.765 : Johant Lakey-Beitia, Deborah Doens, D Jagadeesh Kumar, Enrique Murillo, Patricia L Fernandez, KS Rao, Armando A Durant-Archibold1, Clinical Interventions in Aging · May 2017, DOI: 10.2147/CIA.S134605,“Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery”.
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