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CA00043  Lycopene Anti-apoptic agent - preventing loss of Bcl2 and Bcl-xL, preventing accumulation of Bax, preventing accumulation or release of Cytochrome C, and preventing accumulation or activation of Caspase 3 (Ref.782).    CA00309  β-Carotene Anti-apoptic agent - preventing loss of Bcl2, preventing accumulation of Bax, and preventing accumulation or activation of Caspase 3 (Ref.782). β-carotene derived retinoid acids bind with retinoid acid receptor (PAR) and retinoid X receptor are dimerized and regulate genes during neurogenesis and neuroprotection against apoptosis (Ref.782).    CA00328  Zeaxanthin Anti-apoptic agent - preventing accumulation or activation of Caspase 3 (Ref.782).    CA00502  (3S,3'S)-Astaxanthin Anti-apoptic agent - preventing loss of Bcl2, preventing accumulation of Bax, and preventing accumulation or activation of Caspase 3 (Ref.782).    CA00519  Fucoxanthin Anti-apoptic agent - preventing loss of Bcl2, preventing accumulation of Bax, preventing accumulation or release of Cytochrome C, and preventing accumulation or activation of Caspase 3 (Ref.782).    CA00597  Lutein Anti-apoptic agent - preventing loss of Bcl2 and Bcl-xL, preventing accumulation of Bax, preventing accumulation or release of Cytochrome C, and preventing accumulation or activation of Caspase 3 (Ref.782). Fucoxanthin potentially binds directly to amyloid-β, preventing formation of pathological amyloid-beta fibril (Ref.782). Ref.782 : Han-A Park et al., Molecules 2020, 25, 3453, “Anti-Apoptotic Effects of Carotenoids in Neurodegeneration”, doi:10.3390/molecules25153453. Ref.783 : Wang, J.; Li, L.; Wang, Z.; Cui, Y.; Tan, X.; Yuan, T.; Liu, Q.; Liu, Z.; Liu, X. , J. Nutr. Biochem. 2018, 56, 16–25., “Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress.” . Ref.784 : Hira, S.; Saleem, U.; Anwar, F.; Sohail, M.F.; Raza, Z.; Ahmad, B., Biomolecules 2019, 9, 441. “β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease. . Ref.765 : Johant Lakey-Beitia, Deborah Doens, D Jagadeesh Kumar, Enrique Murillo, Patricia L Fernandez, KS Rao, Armando A Durant-Archibold1,  Clinical Interventions in Aging · May 2017, DOI: 10.2147/CIA.S134605,“Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery”.

Since June 15, 2015 by Junko Yabuzaki.